ASSOCIATION BETWEEN ORAL SQUAMOUS CELL CARCINOMA AND SERUM VITAMIN E IN SNUFF USERS AND NON SNUFF USERS IN KHYBER PAKHTUNKHWA PROVINCE OF PAKISTAN

Authors

  • Abbas Saleem Khan Department of Oral Pathology Peshawar Dental College, Riphah International University.
  • Sajjad Ahmad Department of Pathology, Peshawar Medical College, Riphah International University.
  • Zahoorullah Department of Biochemistry, Peshawar Medical College, Riphah International University.
  • Muhammad Rauf Khattak Department of IRNUM (Institute of Radiotherapy and Nuclear Medicine), University campus, Peshawar.
  • Muhammad Mumtaz Khan Department of Pathology Peshawar Medical College, Riphah International University.

DOI:

https://doi.org/10.33279/jkcd.v7i3.535

Keywords:

Oral squamous cell carcinoma, vitamin, Snuff.

Abstract

Objective: To assess the association between oral squamous cell carcinoma (OSCC) and serum vitamin E status in snuff users and nonusers.
Materials and Methods:This comparative cross-sectional study was conducted in Peshawar Medical and Dental College and Institute of Radiotherapy and Nuclear Medicine (IRNUM) Peshawar. This study was carried ou from March 2013 to August 2013.The 50 diagnosed cases of oral squamous cell carcinoma and 50 healthy controls were selected by purposive sampling technique. Among the oral squamous cell carcinoma cases, 25 subjects (group A) were snuffed users, and 25 subjects (group B) were non- snuff users. Among the healthy controls, 25 participants (group C) were snuff users, and 25 participants (group D) were non-snuff users. Blood samples were collected from all 100 participants. Serum vitamin E levels were estimated spectrophotometrically.
Results:Negative association (OR=0.85; p-value=0.838) was observed between oral squamous cell carcinoma and low serum vitamin E status. Negative (OR=0.02) but statistically significant association (p-value=0.0036) was found between serum vitamin E status and well-differentiated squamous cell carcinoma only. Positive (OR=2.37) but statistically insignificant (p=0.24) association was observed between vitamin E status and snuff usage among healthy controls.
Conclusion:There is no positive association between OSCC with low serum vitamin E status amongst snuff dippers and non-snuff dippers.

Downloads

Published

2017-12-31

How to Cite

Khan, A. S. ., Sajjad Ahmad, Zahoorullah, Muhammad Rauf Khattak, & Muhammad Mumtaz Khan. (2017). ASSOCIATION BETWEEN ORAL SQUAMOUS CELL CARCINOMA AND SERUM VITAMIN E IN SNUFF USERS AND NON SNUFF USERS IN KHYBER PAKHTUNKHWA PROVINCE OF PAKISTAN . JOURNAL OF KHYBER COLLEGE OF DENTISTRY, 7(3), 9–15. https://doi.org/10.33279/jkcd.v7i3.535

Issue

Vol. 7 No. 3 (2017): Journal of Khyber College of Dentistry

Section

Original Article

License

Copyright (c) 2017 Abbas Saleem Khan, Sajjad Ahmad, Zahoorullah, Muhammad Rauf Khattak, Muhammad Mumtaz Khan

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

You are free to:

  1. Share — copy and redistribute the material in any medium or format
  2. Adapt — remix, transform, and build upon the material
  3. The licensor cannot revoke these freedoms as long as you follow the license terms.

Under the following terms:

  1. Attribution — You must give appropriate credit , provide a link to the license, and indicate if changes were made . You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.
  2. NonCommercial — You may not use the material for commercial purposes .
  3. No additional restrictions — You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits.

Most read articles by the same author(s)