IMMUNOREACTIVITY OF MMP-9 IN TISSUE SAMPLES OF ORAL POTENTIALLY MALIGNANT DISORDERS AND NORMAL ORAL MUCOSA
DOI:
https://doi.org/10.33279/jkcd.v15i02.744Keywords:
Matrix Metalloproteinase-9, Oral potentially malignant, normal oral mucosa, ImmunohistochemistryAbstract
Objectives: This study's objective is to evaluate the immunoreactivity of MMP-9 in tissue samples from diagnosed cases of oral precancerous conditions and from normal oral mucosa.
Materials and Methods: This study evaluated MMP-9 immunoreactivity in normal oral mucosa and oral potentially malignant disorders (OPMDs). Tissue samples were collected from surgical procedures and departmental archives, with H&E and immuno-histochemical staining performed following standard protocols. Immunoreactivity was assessed based on staining intensity and positive cell percentage, using spleen tissue as a positive control. Statistical analysis showed signifi cant differences in age between normal mucosa and OPMD cases (p < 0.05).
Results: MMP-9 expression was high in OPMDS patients than in normal oral mucosa. While comparing the degree of MMP-9 expression among OPMDs and normal oral mucosa , a statistically significant relationship was found.
Conclusion: MMP-9 expression was shown to be higher in OPMDs than in normal oral mucosa. Evaluation of MMP-9 biomarker may be clinically significant in OPMDs and may be utilized as a diagnostic indicator for OPMDs.
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