ALTERATIONS OF CIRCULATING TUMOUR DNA AS A BIOMARKER IN ORAL SQUAMOUS CELL CARCINOMA: A SYSTEMATIC REVIEW

Authors

  • Samrina Mohammad Department of Oral Pathology, Khyber College of Dentistry Peshawar
  • Ihsan Ullah Institute of Basic Medical Sciences, Khyber Medical University Peshawar
  • Asif Ali Institute of Pathology and Diagnostic Medicine, Khyber Medical University Peshawar
  • Umer Farooq Department of Oral Pathology, Khyber College of Dentistry Peshawar
  • Khurshid Ali Department of Oral Pathology, Khyber College of Dentistry Peshawar
  • Sabreen Hassan Department of Oral Pathology, Khyber College of Dentistry Peshawar
  • Muhammad Uzair Khan Institute of Basic Medical Sciences, Khyber Medical University Peshawar

DOI:

https://doi.org/10.33279/jkcd.v12i2.61

Keywords:

OSCC, ctDNA, Biomarker, Mutation, Alterations

Abstract

Objective:To investigate the literature on genetic abnormalities of DNA in blood and saliva from OSCC patients, to report diagnostic accuracy, and to address the possibilities for a diagnostic or recurrence monitoring test based on circulating tumor DNA (ctDNA).
Methods and materials:A systematic search was performed in PubMed for articles published between 2013 and 2021. The search terms used were “circulating tumor DNA in oral squamous cell carcinoma”.
Results:We found eleven relevant studies, of which four (36.36%) prospective population studies were included. In all studies ctDNA were used as biomarker in OSCC. Two studies were looked into ctDNA somatic and methylated DNA mutations in OSCC. Another study found 90% of the ctDNA alteration and one study identifi ed PD-L1gene, which plays an important role in primary cancers based on tumour size, as well as disease-specific survival.
Conclusion: This study concluded that the use of ctDNA as biomarkers in OSCC clinical routine will help to establish consistent strategies for the early detection of cancer lesions enable early prevention and support the development of targeted therapies.

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Published

2022-06-30

How to Cite

Samrina Mohammad, Ihsan Ullah, Asif Ali, Umer Farooq, Khurshid Ali, Sabreen Hassan, & Muhammad Uzair Khan. (2022). ALTERATIONS OF CIRCULATING TUMOUR DNA AS A BIOMARKER IN ORAL SQUAMOUS CELL CARCINOMA: A SYSTEMATIC REVIEW. JOURNAL OF KHYBER COLLEGE OF DENTISTRY, 12(2), 41–45. https://doi.org/10.33279/jkcd.v12i2.61

Issue

Vol. 12 No. 2 (2022): Journal of Khyber College of Dentistry

Section

Original Article

License

Copyright (c) 2022 Samrina Mohammad, Ihsan Ullah, Asif Ali, Umer Farooq, Khurshid Ali, Sabreen Hassan, Muhammad Uzair Khan

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