ATTENUATION OF CISPLATIN ASSOCIATED TESTICULAR TOXICITY BY 6-HYDROXYFLAVONE
DOI:
https://doi.org/10.33279/jkcd.v9i02.373Keywords:
6-Hydroxyflavone, Chemotherapy induced testicular damage, Flavonoids and testes, Anti-fertility, Natural products.Abstract
Objectives:
Cisplatin is an effective anticancer drug for the treatment of various malignancies. However, cisplatin use is associated with different adverse effects including its toxicological propensity for testicular damage. Flavonoids have shown to possess strong antioxidant property and have a protective influence on human body. In the present study, the flavonoid, 6-hydroxyflavone was investigated against cisplatin associated testicular toxicity in rats.
Materials & Methods:
The animals were daily treated with 6-hydroxyflavone at doses of 25 and 50 mg/kg for consecutive 15 days, while cisplatin was injected as a single dose (7.5 mg/kg, i.p.) on day 10 of the experiment. The testicular tissue was collected and malondialdehyde (MDA), glutathione (GSH), and superoxide dismutase (SOD) were measured. The tissues were also processed for histopathological evaluation.
Results:
Cisplatin produced marked oxidative stress (increased MDA and decreased GSH and SOD) and caused degenerative changes in the germinal epithelium of the seminiferous tubules. Daily treatment with the tested doses of 6-hydroxyflavone attenuated the cisplatin-induced oxidative stress in the testes by significantly decreasing the levels of MDA, and increasing the contents
of GSH and activity of SOD. Moreover, 6-hydroxyflavone also protected the germinal epithelium from the toxicological assertion of cisplatin as no significant histopathological aberrations were observed.
Conclusion:
These finding suggest that flavonoids in general and 6-hydroxyflavone in particular may be used for the management of anti-cancer drugs associated adverse-effects particularly for their propensity towards reproductive system.
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Copyright (c) 2019 Zia Ur Din, Shabnum Amir, Muhammad Haris, Naila Ismail, Noman Ullah Wazir, Muhammad Shahid, Rahim Ullah, Nisar Ahmad, Umar Farooq, Ihsan Ullah
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