DIFFERENT HISTOPATHOLOGICAL GRADES OF ORAL SQUAMOUS CELL CARCINOMA IN PATIENTS WITH HISTORY OF SNUFF DIPPING
DOI:
https://doi.org/10.33279/jkcd.v6i02.215Keywords:
Histopathological grades, Squamous cell carcinoma, Snuff dippingAbstract
Objective: To determine the frequency of different histopathological grades of squamous cell carcinoma in patients with history of snuff dipping.
Material and Methods: This descriptive cross sectional study was conducted at Department of Oral and Maxillofacial Surgery Khyber College of Dentistry. A total of 157 patients were observed using 27.5% proportion of grade 2 of oral squamous cell carcinoma on histopathology among snuff dippers, 95% confidence interval and 7% margin of error under World Health Organization sample size calculations. Study duration was six months in which consecutive (non probability) sampling technique was used for sample collection.
Results: In this study mean age of the patients was 62 years with SD ± 3.71. Eighty three percent patients were male and 17% patients were female. Forty two percent patients had snuff dipping from 20-30 years and 58% patients had snuff dipping from 31-40 years. Sixty six percent patients had grade 1 oral squamous cell carcinoma, 30% patients had grade 2 oral squamous cell carcinoma and 4% patients had grade 3 oral squamous cell carcinoma.
Conclusions: Our study concluded that well differentiated Oral squamous cell carcinoma (G1) is the most common grade of the tumour in those patients with positive history of snuff dipping. Grading of this tumour favours good prognosis if the lesion is diagnosed at an early stage. Snuff dipping is the most common form of smokeless tobacco use in this part of the world. Snuff dipping is a strong risk factor in the aetiology of oral squamous cell carcinoma.
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Copyright (c) 2016 Ajmal Khan, Anjum Iqbal, Muhammad Haleem, Muslim Khan, Atta ur Rehman, Qiam ud Din
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