ASSESSMENT OF THE PROPERTIES (SENSITIVITY AND SPECIFICITY) OF CYFRA 21-1 IN THE DIAGNOSIS OF ORAL SQUAMOUS CELL CARCINOMA
DOI:
https://doi.org/10.33279/jkcd.v16i01.977Keywords:
CYFRA 21-1, Oral Squamous Cell Carcinoma, Sensitivity, SpecificityAbstract
Objectives: To evaluate the sensitivity and specifi city of the salivary CYFRA 21-1, to be applied in a defined clinical context.
Materials and Methods: A case-control design was employed, conducted in Sardar Begum Dental College, and the data was collected from Khyber College of Dentistry, with a total of 101 diagnosed but untreated individuals of Oral squamous cell carcinoma (cases) with biopsy reports and 101 controls, non-disease (matched for age and gender) were selected for the research. Saliva samples were taken from both groups and followed by, testing CYFRA 21-1 using a commercially available ELISA kit to determine its concentration and its sensitivity and specificity.
Results: The findings demonstrated that CYFRA 21-1 exhibits strong diagnostic performance for Oral squamous cell carcinoma, with a sensitivity of 93.6%, Specifi city of 93%, a positive predictive value of 92.5%, and a negative predictive value of 93.75%.
Conclusion: The results highlight the validity of CYFRA 21-1, as a promising biomarker of the saliva for the very initial identification of Oral Squamous Cell Carcinoma.
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Copyright (c) 2026 Gulmeena Masood, Sofia Haider Durrani, Syed Amjad Abbas, Iqra Muhammad Khan, Ambreen, Bisma Fayyaz, Sana Salam
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