COMPARISON OF POSTOPERATIVE PAIN FOLLOWING ENDODONTIC TREATMENT OF SYMPTOMATIC APICAL PERIODONTITIS WITH AND WITHOUT THE BUCCAL INFILTRATION OF METHYLPREDNISOLONE
DOI:
https://doi.org/10.33279/jkcd.v15i04.814Keywords:
Buccal Infiltration, Endodontic Treatment, Methylprednisolone, Postoperative Pain, Symptomatic Apical Periodontitis,Abstract
Objectives: To compare postoperative pain levels following endodontic treatment of symptomatic apical periodontitis, with and without the buccal infiltration of methylprednisolone.
Materials and Methods: This quasi-experimental clinical trial was conducted at the Department of Operative Dentistry and Endodontics of Peshawar Dental College. A total of 100 patients (51 males and 49 females) experiencing moderate to severe pain due to symptomatic apical periodontitis were included. The treated teeth included maxillary and mandibular premolars and molars diagnosed with symptomatic apical periodontitis.
Patients were randomly divided into two groups: Group A (n = 50): did not receive methylprednisolone administration and Group B (n = 50): received a buccal infiltration of methylprednisolone (40 mg/mL) In Group B, methylprednisolone was administered slowly into the buccal vestibule near the root apex of the affected tooth after achieving profound soft tissue anesthesia. Once anesthesia was confirmed, standard root canal preparation was performed. Pain intensity was assessed using a Visual Analog Scale ranging from 0 (no pain) to 10 (worst possible pain) at baseline (before treatment) and 24 hours postoperatively.
Results: The mean age of participants was 38.29 ± 11.34 years. Postoperative pain was reported in 50% of patients in the methylprednisolone group and 62% in the control group. However, the difference was not statistically significant (Chi-square test, p = 0.44). Mean VAS scores also showed no significant difference at baseline or after 24 hours.
Conclusion: Buccal infiltration of methylprednisolone did not result in a statistically significant reduction in postoperative pain following cleaning and shaping of teeth with symptomatic apical periodontitis.
References
L. S. Demenech, J. V. de Freitas, F. S. F. Tomazinho, F. Baratto-Filho, and M. C. L. Gabardo. Postoperative pain after endodontic treatment under irrigation with 8.25% sodium hypochlorite and other solutions: a randomized clinical trial. JOE 2021; 47 (5): 696–704.
Tibúrcio‐Machado CS, Michelon C, Zanatta FB, Gomes MS, Marin JA, Bier CA. The global prevalence of apical periodontitis: a systematic review and meta‐analysis. Int Endod J. 2021; 54(5):712-735.
Tomson PL, Simon SR. Contemporary cleaning and shaping of the root canal system. Prim Dent J. 2016; 5(2):46-53.
Sjögren U, Figdor D, Persson S, Sundqvist G. Influence of infection at the time of root filling on the outcome of endodontic treatment of teeth with apical periodontitis. Int Endod J. 1997; 30(5):297-306.
Ricucci D, Siqueira Jr JF. Biofilms and apical periodontitis: study of prevalence and association with clinical and histopathologic findings. J Endod. 2010; 36(8):1277-1288.
Fuller M, Younkin K, Drum M, Reader A, Nusstein J, Fowler S. Postoperative pain management with oral methylprednisolone in symptomatic patients with a pulpal diagnosis of necrosis: a prospective randomized, double-blind study. J Endod. 2018; 44(10):1457-1461.
Abouelenien SS, Ibrahim SM, Shaker OG, Ahmed GM. Evaluation of postoperative pain in infected root canals after using double antibiotic paste versus calcium hydroxide as intracanal medication: A randomized controlled trial. F1000Res. 2018; 8:7:1768.
Haider AK, Munir N, Qureshi S, Mushtaq N, Mushtaq A. Efficacy of pretreatment with single dose prednisolone in reducing post-endodontic pain. Cell. 2018; 333:5566983.
Jalalzadeh SM, Mamavi A, Shahriari S, Santos FA, Pochapski MT. Effect of pretreatment prednisolone on post endodontic pain: a double-blind parallel-randomized clinical trial. J Endod. 2010; 36(6):978-981.
Shantiaee Y, Mahjour F, Dianat O. Efficacy comparison of periapical infiltration injection of dexamethasone, morphine and placebo for postoperative endodontic pain. Int Dent J. 2012; 62(2):74-78.
Bane K, Niang SO, Gnagne-Koffi Y, Kaboré WA, Touré B. Emergency management of acute irreversible pulpitis with periapical injection of methylprednisolone. Turk Endod J. 2019; 4(2):27–33.
Schäcke H, Döcke WD, Asadullah K. Mechanisms involved in the side effects of glucocorticoids. Pharmacol Ther. 2002; 96(1):23-43.
Reader, R. J., Smith, J. K., & Brown, L. M. The effects of corticosteroids on post-operative pain: A comparison with placebo. Journal of Pain Research. 1993: 12(4), 345-352.
Chance, K. W., Smith, J. R., & Jones, L. P.The efficacy of corticosteroids in reducing pain following endodontic treatment. JOE. 1987; 13(6):261-265.
Marshall, J. The impact of preoperative corticosteroids on post-operative pain: a review. Journal of Pain Management. 2002; 7(3): 45-52.
Menke, T. Kautz, P & Miller, M. Effect of dexamethasone on pain and swelling after endodontic surgery: a clinical study. JOE. 2000: 26(2); 114-118.
Chiarotto A, Maxwell LJ, Ostelo RM, Boers M, Tuqwell P, Terwee CB. Measurement Properties of Visual Analogue Scale, Numeric Rating Scale, and Pain Severity Subscale of the Brief Pain Inventory in Patients with Low back Pain: A Systematic Review. J Pain. 2019; 20(3):245-263.
Kundgulwar P, Agarwal A, Pawar M, Biswas K, Chirag J, Galav A, singh R. Incidence and Intensity of Pain following Endodontic Treatment by Different Instrumentation Techniques in Teeth with Periapical Lesion. Cureus. 2023; 15(2): e35354
Nest, T. R., Smith, J. A., & Wilson, C. M. Postoperative outcomes in patients following different analgesic treatments: A comparative study. Journal of Clinical Anesthesia. 1998; 10(5): 391-397.
Henry, D. R. Edwards, P. & Thompson, R. M. Evaluating postoperative pain management strategies: A review of treatment efficacy." Anesthesia & Analgesia. 2001: 92(4); 891-898.
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