KNOWLEDGE ABOUT ROLE OF HPV AS A RISK FACTOR OF ORAL SQUAMOUS CELL CARCINOMA AMONG DENTISTS IN ASIA. A SYSTEMIC REVIEW
DOI:
https://doi.org/10.33279/jkcd.v15i01.787Keywords:
Knowledge, Factors,, OSCC, Risk, HPVAbstract
Objectives: To assess the awareness and the knowledge among dentists of Asia about the Human Papillo mavirus (HPV) as a risk factor in oral squamous cell carcinoma (OSSC).
Materials and Methods: This systemic review was conducted on cross-sectional and observational research to assess dentists knowledge of HPV as a risk factor for OSCC in Asia. Up until August 9, 2024, databases including PubMed, Web of Science, Scopus, and Google Scholar were searched for relevant studies. Studies applying dentists as participants carried out in Asian nations met the eligibility requirements. The Joanne Briggs Institute (JBI) criteria for analytical cross-sectional research was used to assess the quality of the investigations.
Results: Studies from Asian countries, including Saudi Arabia, Turkey, Malaysia, Indonesia, and Pakistan, met the inclusion criteria. The fi ndings revealed signifi cant disparities in knowledge across regions. In Indonesia, 98% of dentists demonstrated a high understanding of HPV’s role in OSCC, while in Pakistan and Malaysia, many dentists were unaware of this association. Gender and education level infl uenced awareness, with male students showing more knowledge about HPV's link to oropharyngeal cancer, while female students were better informed about HPV vaccination. These results highlight the need for enhanced education and training programs to address these gaps.
Conclusion: Asian nations have an increased incidence of oral squamous cell carcinoma (OSCC), with tobacco use, alcohol intake, and chewing betel quid as major risk factors. There is growing evidence that HPV, specifically subtypes HPV-16 and HPV-18, plays a major role in the development of OSCC. In Asia, dentists are still mostly unaware of the role HPV plays in OSCC risk factor education and early diagnosis, despite their critical role in this respect.
References
World Health Organisation (2020). Cancer fact sheets – lip, oral cavity. Retrieved from: https://gco.iarc.who.int/media/globocan/facts heets/cancers/1-lip-oral-cavity-fact-sheet
Rai P, Ng A, Intekhab I, Sim YF, Lai CWM, Loh JSP. Oral cancer in Asia – A systematic review. Advances in Oral and Maxillofacial Surgery 2022;(8):100366. DOI: https://doi.org/10.1016/j.adoms.2022.100366
Nokovitch L, Maquet C, Crampon F, Taihi I, Roussel LM, Obongo R, Virard F, Fervers B, Deneuve S. Oral cavity squamous cell carcinoma risk factors: State of the art. Journal of Clinical Medicine 2023; 12(9):3264 DOI: https://doi.org/10.3390/jcm12093264
Lechner M, Liu J, Masterson L, & Fenton TR. HPV-associated oropharyngeal cancer: Epidemiology, molecular biology and clinical management. Nature Reviews. Clinical Oncology 2022; 19(5): 306–327. DOI: https://doi.org/10.1038/s41571-022-00603-7
Syrjänen S, Lodi G, von Bültzingslöwen I, Aliko A, Arduino P, Campisi G, Challacombe S, Ficarra G, Flaitz C, Zhou HM, Maeda H, Miller C, Jontell M. Human papillomaviruses in oral carcinoma and oral potentially malignant disorders: A systematic review. Oral Diseases 2011; 17,:58–72. DOI: https://doi.org/10.1111/j.1601-0825.2011.01792.x
Shaikh MH, Khan AI, Sadat A, Chowdhury AH, Jinnah SA, Gopalan V, Lam AK, Clarke DTW, McMillan NAJ, Johnson NW. Prevalence and types of high-risk human papillomaviruses in head and neck cancers from Bangladesh. BMC Cancer 2017); 17(1): 792. DOI: https://doi.org/10.1186/s12885-017-3789-0
Katirachi SK, Gronlund MP, Jakobsen KK, Gronhoj C, von Buchwald C. The prevalence of HPV in oral cavity squamous cell carcinoma. Viruses 2023; 15(2): 451.
Lortet-Tieulent J, Georges D, Bray F, Vaccarella S. Profiling global cancer incidence and mortality by socioeconomic development. International Journal of Cancer 2020; 147(11): 3029–3036. DOI: https://doi.org/10.1002/ijc.33114
Rahadiani N, Habiburrahman M, Stephanie M, Handjari DR, Krisnuhoni E. Estimated projection of oral squamous cell carcinoma annual incidence from twenty years registry data: A retrospective cross-sectional study in Indonesia. PeerJ 2020; 11: e15911.
Sung H, Ferlay J, Siegel RL, Laversanne M, Soer jomataram I, Jemal A, Bray F. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians 2021; 71(3) :209–249. DOI: https://doi.org/10.3322/caac.21660
Huang K, Ni G, Ma B, Chen S, Luan Y, Wang T, Walton S, Frazer I, Liu X, Pan X. Importance of human papillomavirus infection in squamous cell carcinomas of the tongue in Guangdong Province, China. The Journal of International Medical Research 2020; 48(1): 300060519897187 DOI: https://doi.org/10.1177/0300060519897187
Yang L, Dan W, Yu X, He Y, Shi C, Yi J, Gao L, Li S, Zhou T, Ma Y. Development and validation of a self-administered screening test for betel quid use disorders in betel quid chewers in Hunan, China. International Journal of General Medicine 2022: 15: 8183– 8190. DOI: https://doi.org/10.2147/IJGM.S386539
Beachler DC, D'Souza G. Oral human papillomavirus infection and head and neck cancers in HIV-infected individuals. Current Opinion in Oncology 2013; 25(5):503–510. DOI: https://doi.org/10.1097/CCO.0b013e32836242b4
Tumban E. A current update on human papillomavirus-associated head and neck cancers. Viruses 2019; 11(10): 922. DOI: https://doi.org/10.3390/v11100922
Katirachi, S. K., Gronlund, M. P., Jakobsen, K. K., Gronhoj, C., & von Buchwald, C. (2023). The prevalence of HPV in oral cavity squamous cell carcinoma. Viruses, 15(2), 451. https://doi.org/10.3390/v15020451 DOI: https://doi.org/10.3390/v15020451
Rahadiani, N., Habiburrahman, M., Stephanie, M., Handjari, D. R., & Krisnuhoni, E. (2023). Estimated projection of oral squamous cell carcinoma annual incidence from twenty years registry data: A retrospective cross-sectional study in Indonesia. PeerJ, 11, e15911 DOI: https://doi.org/10.7717/peerj.15911
Melo, B. A. C., Vilar, L. G., Oliveira, N. R., Lima, P. O., Pinheiro, M. B., Domingueti, C. P., & Pereira, M. C. (2021). Human papillomavirus infection and oral squamous cell carcinoma –A systematic review. Brazilian Journal of Otorhinolaryngology, 87(3), 346–352. https:// doi. org/10.1016/j.bjorl.2020.10.017 DOI: https://doi.org/10.1016/j.bjorl.2020.10.017
Ma LL, Wang YY, Yang ZH, Huang D, Weng H, Zeng XT. Methodological quality (risk of bias) assessment tools for primary and secondary medical studies: what are they and which is better? Mil Med Res. 2020;7(1):7. https://doi: 10.1186/s40779-020-00238-8. DOI: https://doi.org/10.1186/s40779-020-00238-8
Alqhtani N, Alenazi A, Hattan E, Alqahtani R, Alqahtani A, Alqutaym O, et al. Knowledge of dental practitioners in Saudi Arabia concerning human papillomavirus (HPV) and its correlation with oral cancers. Int J Med Dent. 2020;24(3):456- 63.
Özdede M, Bağci N, Gündüz T, Peker I. Evaluation of knowledge and awareness of dentists and dental students about human papillomavirus vaccination and oropharyngeal cancer relationship. Clin Exp Health Sci. 2020;10(3):309 DOI: https://doi.org/10.33808/marusbed.752850
Arora S, Ramachandra SS, Squier C. Knowledge about human papillomavirus (HPV) related oral cancers among oral health professionals in university setting-a cross sectional study. J Oral Biol Craniofac Res. 2018;8(1):35-9 DOI: https://doi.org/10.1016/j.jobcr.2017.12.002
Hasibuan S, Rahma SSA. Medan Dentist’s Knowledge Level About Oral Squamous Cell Carcinoma Associated Human Pappiloma virus. B-Dent Jurnal Kedokteran Gigi Universitas Baiturrahmah;2023: 10(1):55-62 DOI: https://doi.org/10.33854/jbd.v10i1.1250
Lingam AS, Koppolu P, Alhussein SA., Abdelrahim RK., Abusalim GS., ElHaddad S, Asrar S, Nassani MZ., Gaafar SS, Bukhary FMT., AlGhamdi, A. S., Barakat, A., Noushad, M., & Almoallim, H. (2022). Dental Students' Perception, Awareness and Knowledge About HPV Infection, Vaccine, and Its Association with Oral Cancer: A Multinational Study. Infection and drug resistance, 15, 3711–3724. DOI: https://doi.org/10.2147/IDR.S365715
Alsharif MT, Alsahafi E. Assessing the Knowledge of HPV-Associated Oropharyngeal Squamous Cell Carcinoma, HPV Vaccination, and Practice Scope among Saudi Dental Students in the Western Region. Healthcare. 2024; 12(9):905. DOI: https://doi.org/10.3390/healthcare12090905
Roslan, N., Mohd Adnan, M. I. H., Abdul Rahman, N. S. A., Md Bohari, N. F., & Hassan, E. H. (2024). Knowledge and Awareness of Human Papillomavirus Vaccination for Oral Cancer Prevention among Dental Practitioners, Students, and Patients at UiTM Faculty of Dentistry, Malaysia. Compendium of Oral Science, 11(1), 68–78. https://doi.org/10.24191/cos.v11i1.26040 DOI: https://doi.org/10.24191/cos.v11i1.26040
Farsi NJ, Al Sharif S, Al Qathmi M, Merdad M, Marzouki H, Merdad L. Knowledge of human papillomavirus (HPV) and oropharyngeal cancer and acceptability of the HPV vaccine among dental students. Asian Pac J Cancer Prev. 2020;21(12):3595-603. DOI: https://doi.org/10.31557/APJCP.2020.21.12.3595
Keser G, Yılmaz G, Pekiner FN. Assessment of knowledge level and awareness about human papillomavirus among dental students. J Cancer Educ. 2021;36(4):664-9. DOI: https://doi.org/10.1007/s13187-019-01683-3
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