COMPARISON OF IMMUNOHISTOCHEMICAL EXPRESSION OF INSULIN LIKE GROWTH FACTOR 1 RECEPTOR (IGF-1R) IN BENIGN AND MALIGNANT SALIVARY GLAND TUMORS

Authors

  • Mehreen Malik Department of Oral Pathology, Abbottabad International Medical Institute, Abbottabad.
  • Sadaf Alam Department of Pathology Peshawar Medical and Dental College, Peshawar.
  • Sara Ziaullah Department of Pathology Peshawar Medical and Dental College, Peshawar.
  • Maria Hanif Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar.
  • Noor Jahanzeb Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar.
  • Ayesha Khitab Department of Oral Pathology, Peshawar Medical and Dental College, Peshawar.

DOI:

https://doi.org/10.33279/jkcd.v14i03.609

Keywords:

Insulin-like Growth Factor 1 Receptor (IGF-1R), Salivary Glands, Benign Salivary Gland Tumor, Malignant Salivary Gland tumor

Abstract

Objectives: To evaluate the difference in immunohistochemical expression of insulin-like growth
factor-1 receptor (IGF-1R) in diagnosed cases of benign and malignant salivary gland tumors.
Materials and Methods: This Comparative Cross-Sectional Study was conducted at the department of Pathology, Peshawar Medical and Dental College, Peshawar. A total of 100 Salivary Gland Tumors from 56 male and 44 female patients were included in the study, with an average age of 43.50 ± 15.21. The Immunohistochemical Expression of Insulin-like Growth Factor 1 Receptor was determined on both benign and malignant salivary gland tumors using the Bio SB Polyclonal IGF-1R antibody (rabbit, BT-AP04398). The collected data were analyzed using SPSS version 25.
Results: For the immunohistochemical expression of IGF-1R on benign and malignant salivary
gland tumors, the Allred Scoring method was utilized. P value of <0.05 was considered significant,
but no positive signifi cance was found between the expression of IGF-1R and salivary gland tumors.
Conclusion: IGF1R expression was positive in various SGTs but no statistically significant difference was seen in multiple histopathological types of benign and malignant SGT

Author Biography

Sadaf Alam, Department of Pathology Peshawar Medical and Dental College, Peshawar.

 

 

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Published

2024-09-30

How to Cite

Malik, M. ., Sadaf Alam, Sara Ziaullah, Maria Hanif, Noor Jahanzeb, & Ayesha Khitab. (2024). COMPARISON OF IMMUNOHISTOCHEMICAL EXPRESSION OF INSULIN LIKE GROWTH FACTOR 1 RECEPTOR (IGF-1R) IN BENIGN AND MALIGNANT SALIVARY GLAND TUMORS. JOURNAL OF KHYBER COLLEGE OF DENTISTRY, 14(03), 8–12. https://doi.org/10.33279/jkcd.v14i03.609

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