IMMUNOEXPRESSION OF TWIST IN PATIENTS PRESENTING WITH ODONTOGENIC KERATOCYST

Authors

  • Ihsan Ullah Institute Of pathology and diagnostic Medicine, KMU peshawar
  • Naveed Khan Department of Dentistry. Ayub Medical College. Abottabad
  • Abdur Rehman Department of Dentistry. Ayub Medical College. Abottabad
  • Shagufta Naeem Department of Pathology. Ayub Medical College. Abottabad
  • Khurshid Ali Department of Oral Pathology. Khyber College of Denstistry.Peshawar
  • Fouzia Tabbassum Department of Dentistry. Ayub Medical College. Abottabad

DOI:

https://doi.org/10.33279/jkcd.v12i04.5

Abstract

Objectives: To evaluate the immunohistochemical expression of Twist in patients presenting with
Odontogenic keratocyst.
Materials and Methods: This study was performed at the department of Pathology, “Khyber
Medical University Peshawar” from January 2022 to June 2022.A total of 83 patients meeting
the inclusion criteria were included. All the patients were diagnosed for OKC according to WHO
criteria.Twist immunoexpression of OKC blocks were peroformed according to IHC protocol.
SPSS version 22 was used for the analysis of data.
Results: Out of eighty three cases of Odontogenic keratocyst, 51 cases were positively stained
for Twist (61.4%),while 32 cases were negatively stained (38.6%).Amongst the positively stained
cells 17 cases (20.5%) were mild positive,16 cases (19.3%) showed moderate immunopositvity
and eighteen cases (21.7%) exhibited strong positivity for Twist.
Conclusion: It is concluded that twist immunohistochemiacal analysis shows negative to strong
positive results in odontogenic keratocyst, suggesting its possible neoplastic nature.

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Published

— Updated on 2023-02-27

How to Cite

Ullah, I. ., Khan, N., Rehman, A., Naeem, S., Ali, K., & Tabbassum, F. (2023). IMMUNOEXPRESSION OF TWIST IN PATIENTS PRESENTING WITH ODONTOGENIC KERATOCYST. JOURNAL OF KHYBER COLLEGE OF DENTISTRY, 12(04), 09–13. https://doi.org/10.33279/jkcd.v12i04.5

Issue

Vol. 12 No. 04 (2022): JOURNAL OF KHYBER COLLEGE OF DENTISTRY

Section

Original Article

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Copyright (c) 2022 Ihsan Ullah, Naveed Khan, Abdur Rehman, Shagufta Naeem, Khurshid Ali, Fouzia Tabbassum

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