POTENTIAL ROLE OF OSTEOCALCIN AND OSTEOPROTEGRIN IN DETERMINING THE CONNECTION BETWEEN RHEUMATOID ARTHRITIS AND PERIODONTITIS: PERSPECTIVE CASE STUDY FROM LOCAL POPULATION OF PUNJAB, PAKISTAN

Authors

  • Marryam Riaz Department of Physiology Department Azra Naheed Dental College
  • Zartashia Arooj Department of Science of Dental Materials Azra Naheed Dental College
  • Muhammad Sumair Farooq Department of Oral Biology Department Azra Naheed Dental College
  • Sohaib Shujaat PhD Scholar, Leuven University Belgium
  • Ayesha Fahim Department of Oral Biology Department Azra Naheed Dental College
  • Varda Jalil Department of Oral Pathology Department Azra Naheed Dental College

DOI:

https://doi.org/10.33279/jkcd.v10i01.298

Keywords:

Osteocalcin, Osteoprotegerin, Rheumatoid Arthritis, Periodontitis

Abstract

Objective: The aim of this study was to determine the association between Rheumatoid Arthritis and Periodontitis with the help of biomarkers Osteocalcin and Osteoprotegerin.

Materials and Methods: One hundred and twenty subjects were enrolled using consecutive nonprobability sampling for four groups, i.e., controls, clinically diagnosed cases of Rheumatoid Arthritis and Periodontitis, and both after informed consent (attached in the end). Serum Osteocalcin and Osteoprotegerin were measured along with Anti-CCP antibodies and clinical measures of severity of Periodontitis with the help of bleeding on probing (BOP), clinical attachment loss (CAL) and periodontal pocket depth (PPD). ANOVA and post hoc analysis were used to determine the difference of mean in different groups using SPSS 21.

Results: Mean Osteocalcin and Osteoprotegerin were equally distributed among all four groups, although showing trends of increase and decrease in mean plots, respectively (using ANOVA, p value= 0.711, 0.15, respectively). Anti-CCP antibodies, mean CAL, mean BOP, mean PPD, and age were significantly different in four groups (p-value < 0.05 for all). Gender and RA factor were homogenous in all groups (p-value > 0.05 for both), i.e., there was the same number of males and females in each group, and the Rheumatoid factor was equally distributed in patients of all four groups. This proves the fact that the RA factor is just a sensitive test and not a specific test for the diagnosis of Rheumatoid Arthritis.

Conclusion: It is concluded that at the current sample size of 120 subjects, i.e., 30 controls and 30 patients each in with either Rheumatoid Arthritis or Periodontitis or both, there is no difference in mean Osteocalcin and Osteoprotegerin levels.

 

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Published

2020-03-31

How to Cite

Marryam Riaz, Zartashia Arooj, Muhammad Sumair Farooq, Sohaib Shujaat, Ayesha Fahim, & Varda Jalil. (2020). POTENTIAL ROLE OF OSTEOCALCIN AND OSTEOPROTEGRIN IN DETERMINING THE CONNECTION BETWEEN RHEUMATOID ARTHRITIS AND PERIODONTITIS: PERSPECTIVE CASE STUDY FROM LOCAL POPULATION OF PUNJAB, PAKISTAN. JOURNAL OF KHYBER COLLEGE OF DENTISTRY, 10(01), 87–93. https://doi.org/10.33279/jkcd.v10i01.298

Issue

Vol. 10 No. 01 (2020): Journal of Khyber College of Dentistry

Section

Original Article

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Copyright (c) 2020 Marryam Riaz, Zartashia Arooj, Muhammad Sumair Farooq, Sohaib Shujaat, Ayesha Fahim, Varda Jalil

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